ENDOMETRIAL DISEASE IN FEMALES PRESENTING WITH POLYCYSTIC OVARY SYNDROME: A CROSS-SECTIONAL STUDY FROM A TERTIARY CARE HOSPITAL IN KARACHI, PAKISTAN
English
Abstract
Background: Women with polycystic ovary syndrome (PCOs) have a higher frequency of hyperplasia than do women without the condition. PCOS may have complicated effects on the endometrium and contribute to the endometrial diseases seen in women with this illness
Objective: To determine endometrial disease among females presenting with PCOs in a tertiary care hospital in Karachi, Pakistan
Methods: This cross-sectional study was performed at Nehal Hospital, Karachi, Pakistan during January to December, 2022. PCOs diagnosis was established as per 2003 Rotterdam criteria. An 8 MHz transvaginal probe was used to perform transvaginal ultrasound. Patients were interviewed to record their demographic and clinical features. Data was entered in SPSS version 21 to run statistical analysis.
Results: A total of 200 patients were studied with mean age of 30.3 ± 2.6 years. Mean BMI, disease duration and endometrial thickness was 24.2 ± 3.5 kg/m2, 7.6 ± 0.8 years and 6.9 ± 0.2 mm respectively. In total 200 patients, proliferative and secretory endometrium was seen in 46% (n=92) and 28.5% (n=57) respectively. Endometrial hyperplasia was present in 15% (n=48) whereas endometrial carcinoma was found in 5% (n=10) patients. Out of 48 patients with endometrial hyperplasia, 30 were simple hyperplasia without atypia whereas 13 were complex hyperplasia without atypia and 5 were complex hyperplasia with atypia. Endometrial cancer was present in 1.5% (n=3) patients. Age and BMI were significantly higher among patients with abnormal endometrium.
